Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155443 | 0.88 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL5437078 | 0.88 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL4297797 | 0.88 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL29700206 | 0.80 | AOC3 (0.55) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL3924286 | 0.78 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL2306502 | 0.78 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL3924289 | 0.78 | AOC3 (0.53) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL8115632 | 0.76 | AOC3 (0.52) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL7779197 | 0.76 | AOC3 (0.52) | AOC3TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL8113426 | 0.76 | AOC3 (0.52) | AOC3TSHRMAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |