Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626522 | 0.88 | MAPT (0.48) | HPGDSMAPTKDM4ETHRBHPGD | |
| SCHEMBL123032 | 0.83 | ESR2 (0.54) | MAPTKDM4ETHRBHPGDESR2 | |
| Methyl Alcohol SCHEMBL28603193 | 0.82 | ESR2 (0.52) | MAPTKDM4ETHRBHPGDESR2 | |
| SCHEMBL29703403 | 0.81 | HPGD (0.64) | MAPTKDM4ETHRBHPGDPIK3CD | |
| SCHEMBL29703410 | 0.81 | HPGD (0.64) | MAPTKDM4ETHRBHPGDPIK3CD | |
| SCHEMBL2721275 | 0.81 | HPGD (0.64) | MAPTKDM4ETHRBHPGDPIK3CD | |
| SCHEMBL5201368 | 0.79 | GPR119 (0.41) | MAPTKDM4ETHRBHPGDGPR119 | |
| SCHEMBL6988508 | 0.78 | HPGD (0.51) | MAPTKDM4ETHRBHPGDPIK3CD | |
| SCHEMBL13219346 | 0.78 | HPGD (0.51) | MAPTKDM4ETHRBHPGDPIK3CD | |
| SCHEMBL65675 | 0.78 | HPGD (0.51) | MAPTKDM4ETHRBHPGDPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |