Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548886 | 1.00 | MAPT (0.49) | MAPTSIRT6MEN1KMT2AHSD11B1 | |
| SCHEMBL1042577 | 0.81 | SIRT6 (0.58) | MAPTSIRT6MEN1KMT2AHSD11B1 | |
| SCHEMBL1042578 | 0.81 | SIRT6 (0.58) | MAPTSIRT6MEN1KMT2AHSD11B1 | |
| SCHEMBL5725293 | 0.81 | MAPT (0.64) | MAPTSIRT6MEN1KMT2AHSD11B1 | |
| SCHEMBL6073501 | 0.81 | MAPT (0.64) | MAPTSIRT6MEN1KMT2AHSD11B1 | |
| SCHEMBL18436935 | 0.78 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2TNFNOD2NOD1 | |
| SCHEMBL3313704 | 0.77 | ALDH1A1 (0.60) | MAPTSIRT6MEN1KMT2AALDH1A1 | |
| SCHEMBL1749231 | 0.77 | MAPT (0.52) | MAPTSIRT6MEN1KMT2AALDH1A1 | |
| SCHEMBL27938419 | 0.77 | MAPT (0.52) | MAPTSIRT6ALDH1A1TP53LMNA | |
| SCHEMBL6606878 | 0.76 | MAPT (0.61) | MAPTSIRT6MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |