Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FABP1 | P07148 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203118 | 0.83 | HTR6 (0.70) | HTR6HTR2ATSHRALDH1A1KMT2A | |
| SCHEMBL5200624 | 0.80 | HTR6 (0.72) | HTR6HTR2CALDH1A1KMT2ADRD3 | |
| SCHEMBL5201386 | 0.80 | HTR6 (0.72) | HTR6KMT2ADRD3L3MBTL1MAPK1 | |
| SCHEMBL5201056 | 0.80 | HTR6 (0.86) | HTR6KMT2ADRD3MAPK1 | |
| SCHEMBL3322955 | 0.79 | HTR6 (1.00) | HTR6TSHRKMT2ADRD3MAPK1 | |
| SCHEMBL2712002 | 0.79 | L3MBTL1 (0.71) | TSHRALDH1A1GAAKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28345785 | 0.78 | L3MBTL1 (0.69) | TSHRALDH1A1GAAKMT2AL3MBTL1 | |
| SCHEMBL5204332 | 0.77 | HTR6 (0.82) | HTR6KMT2ADRD3 | |
| SCHEMBL5204254 | 0.76 | HTR6 (0.62) | HTR6TSHRALDH1A1KMT2ADRD3 | |
| SCHEMBL14591389 | 0.76 | HTR6 (0.65) | HTR6HTR2AHTR2CALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601358-B1 | 2,5-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-12-19 | — | — | EP | claimed |
| EP-1601358-A1 | 2,5- AND 2,6-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-07 | — | — | EP | claimed |
| US-20040180874-A1 | Substituted tetrahydroisoquinolines and uses thereof | ROCHE PALO ALTO LLC | 2004-09-16 | — | — | US | claimed |
| WO-2004078176-A1 | 2,5- AND 2,6-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-16 | — | — | WO | claimed |
| EP-1601358-B1 | 2,5-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-12-19 | — | — | EP | disclosed |
| US-7196088-B2 | Substituted tetrahydroisoquinolines and uses thereof | ROCHE PALO ALTO LLC (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196088-B2 | Substituted tetrahydroisoquinolines and uses thereof | ROCHE PALO ALTO LLC (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196088-B2 | Substituted tetrahydroisoquinolines and uses thereof | ROCHE PALO ALTO LLC (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1601358-A1 | 2,5- AND 2,6-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-07 | — | — | EP | disclosed |
| US-20040180874-A1 | Substituted tetrahydroisoquinolines and uses thereof | ROCHE PALO ALTO LLC | 2004-09-16 | — | — | US | disclosed |
| WO-2004078176-A1 | 2,5- AND 2,6-SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180874-A1 | Substituted tetrahydroisoquinolines and uses thereof | CYP3A5, CYP4X1, UGT1A1 | HTR6 1252/4885HTR2A 500/4885HTR2C 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.