Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | YWHAG | P61981 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201699 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL24735339 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL24735237 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL24735594 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL24124684 | 0.83 | GAA (0.43) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL1749215 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL1749217 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL1749218 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL20231853 | 0.78 | MAPT (0.54) | ALDH1A1MAPTGFERLMNAMAPK1 | |
| SCHEMBL29890862 | 0.78 | MAPT (0.54) | ALDH1A1MAPTGFERLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |