Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3546921 | 1.00 | PORCN (0.47) | PORCNSYKTSHRALDH1A1BACE1 | |
| SCHEMBL5241338 | 0.86 | SYK (0.50) | PORCNSYKALDH1A1BACE1PLAU | |
| SCHEMBL3554471 | 0.86 | SYK (0.50) | PORCNSYKALDH1A1BACE1PLAU | |
| SCHEMBL3557292 | 0.83 | KDM4E (0.44) | PORCNSYKALDH1A1BACE1GAA | |
| SCHEMBL5203002 | 0.80 | SYK (0.54) | PORCNSYKALDH1A1BACE1PLAU | |
| SCHEMBL3552698 | 0.80 | SYK (0.54) | PORCNSYKALDH1A1BACE1PLAU | |
| SCHEMBL5204927 | 0.76 | EPHX2 (0.50) | ALDH1A1KDM4E | |
| SCHEMBL3549222 | 0.76 | EPHX2 (0.50) | ALDH1A1KDM4E | |
| SCHEMBL9891967 | 0.72 | CNR2 (0.52) | BACE1SMN1; SMN2CNR2CYP2C8CYP2C9 | |
| SCHEMBL3550081 | 0.72 | NPC1 (0.40) | PORCNALDH1A1BACE1CNR2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |