Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 13/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536472 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL31000456 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL5322795 | 0.83 | ALDH1A1 (0.64) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL22094803 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3538126 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL31000427 | 0.80 | MAPT (0.87) | ALDH1A1MAPTL3MBTL1LMNASIRT6 | |
| SCHEMBL3533660 | 0.80 | MAPT (0.87) | ALDH1A1MAPTL3MBTL1LMNASIRT6 | |
| Hydrochloric Acid SCHEMBL3539659 | 0.79 | MAPT (0.84) | ALDH1A1MAPTL3MBTL1LMNANPSR1 | |
| SCHEMBL22094933 | 0.79 | MAPT (0.97) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3536564 | 0.79 | MAPT (0.97) | ALDH1A1MAPTCYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047504-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |