Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348048 | 0.89 | PIK3CD (0.39) | MTORPIK3CAPIK3CDABL1ABL2 | |
| SCHEMBL1346561 | 0.78 | MTOR (0.41) | MTORPIK3CA | |
| SCHEMBL1381331 | 0.77 | FFAR1 (0.33) | — | |
| SCHEMBL1347185 | 0.77 | KIF11 (0.38) | MTORPIK3CAPIK3CDADK | |
| SCHEMBL1349058 | 0.74 | ADK (0.46) | MTORPIK3CAADK | |
| SCHEMBL1346792 | 0.73 | GRM5 (0.41) | ABL1ABL2 | |
| SCHEMBL1349312 | 0.72 | P2RY14 (0.39) | — | |
| SCHEMBL1348545 | 0.72 | KIF11 (0.47) | — | |
| SCHEMBL1346593 | 0.72 | ADK (0.46) | MTORPIK3CAADK | |
| SCHEMBL1348157 | 0.72 | SCN5A (0.42) | MTORPIK3CAADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863818-A1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006099972-A1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-28 | — | — | WO | disclosed |