Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.62 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.62 |
| ▸ | HTR3B | O95264 | 5/20 | 0.62 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.62 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | OGA | O60502 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131162 | 0.81 | HTR3E (0.64) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL15086912 | 0.79 | GRIN2D (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3536632 | 0.79 | KMT2A (0.71) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL15247180 | 0.79 | KMT2A (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3535973 | 0.79 | HTR3A (0.49) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL605990 | 0.77 | HRH4 (0.71) | HRH4HRH3 | |
| SCHEMBL17993354 | 0.77 | OGA (0.48) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL2127461 | 0.77 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL2553138 | 0.76 | MAPT (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL20436562 | 0.76 | HRH3 (0.54) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047504-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |