Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18509268 | 0.76 | MTNR1A (0.68) | HTR6MTNR1AMTNR1BHTR2AMEN1 | |
| SCHEMBL27085284 | 0.76 | HTR6 (0.72) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL31396927 | 0.76 | HTR6 (0.72) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL31390119 | 0.75 | HTR6 (0.70) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL24723312 | 0.74 | HTR6 (0.61) | HTR6MTNR1AMTNR1BHTR2AMEN1 | |
| SCHEMBL29993190 | 0.74 | HTR6 (0.61) | HTR6MTNR1AMTNR1BHTR2AMEN1 | |
| Hydrochloric Acid SCHEMBL31390095 | 0.74 | HTR6 (0.68) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL19235737 | 0.72 | HTR6 (1.00) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL29993252 | 0.72 | HTR6 (1.00) | HTR6MTNR1AMTNR1BHTR2AHTR1A | |
| SCHEMBL29758535 | 0.72 | HTR6 (1.00) | HTR6MTNR1AMTNR1BHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756054-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118539-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |