SCHEMBL5202648

SCHEMBL5202648

Brc1nc(Br)c(Br)[nH]1.C[Si](C)(C)CCOCn1c(Br)nc(Br)c1Br

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.31
DGAT1 O75907 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL67719 0.87 DGAT1 (0.35) PNPDGAT1
SCHEMBL5213310 0.74 DGAT1 (0.37) DGAT1
SCHEMBL19404995 0.74 DGAT1 (0.37) PNPDGAT1
SCHEMBL3634283 0.72 MEN1 (0.34) DGAT1
SCHEMBL23123528 0.72 DGAT1 (0.34) DGAT1
SCHEMBL26965213 0.71 DGAT1 (0.33) DGAT1
SCHEMBL3637817 0.71 DGAT1 (0.33) DGAT1
SCHEMBL67815 0.71 DGAT1 (0.35) DGAT1
SCHEMBL16660842 0.71 DGAT1 (0.43) DGAT1
SCHEMBL6526356 0.70 DGAT1 (0.31) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1802605-A1 IMIDAZOLE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS Amgen, Inc (US) 2007-07-04 EP disclosed
WO-2006044527-A1 IMIDAZOLE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS AMGEN INC. (US) 2006-04-27 WO disclosed