Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28167488 | 0.77 | PARP1 (0.95) | PARP1HTR2CMAOBPNMTCD44 | |
| SCHEMBL19579719 | 0.77 | HTR2C (0.48) | PARP1HTR2CMAOBPNMTCD44 | |
| SCHEMBL33931 | 0.77 | PARP1 (0.95) | PARP1HTR2CMAOBPNMTCD44 | |
| SCHEMBL29429329 | 0.77 | PARP1 (0.95) | PARP1HTR2CMAOBPNMTCD44 | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL22363225 | 0.76 | PARP1 (0.68) | PARP1HTR2CMAOBPNMTCD44 | |
| Bromide SCHEMBL19031040 | 0.76 | PARP1 (0.91) | PARP1HTR2CMAOBPNMTCD44 | |
| Hydrochloric Acid SCHEMBL7007870 | 0.76 | PARP1 (1.00) | PARP1HTR2CMAOBPNMTCD44 | |
| Hydrochloric Acid SCHEMBL27599345 | 0.76 | PARP1 (1.00) | PARP1HTR2CMAOBPNMTCD44 | |
| Bromide SCHEMBL7236242 | 0.76 | PARP1 (0.91) | PARP1HTR2CMAOBPNMTCD44 | |
| SCHEMBL28243677 | 0.76 | PARP1 (0.91) | PARP1HTR2CMAOBPNMTCD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347672-B1 | Benzazepine derivatives | NOVO NORDISK AS (DK) | 1994-03-02 | — | — | EP | claimed |
| EP-0080012-B1 | 6-CHLORO-3-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE, ITS ACID ADDITION SALTS AND ITS USE AS AN INTERMEDIATE | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-09 | — | — | EP | claimed |
| EP-0160513-A1 | Fenoldopam 4', 8-bis-hydrogen sulfates | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-06 | — | — | EP | claimed |
| EP-2934118-B1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2018-01-31 | — | — | EP | disclosed |
| US-20170158597-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2017-06-08 | — | — | US | disclosed |
| US-9630910-B2 | Pesticidal compositions and processes related thereto | DOW AGROSCIENCES LLC (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160037771-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2016-02-11 | — | — | US | disclosed |
| US-9212164-B2 | Pesticidal compositions and processes related thereto | DOW AGROSCIENCES LLC (US) | 2015-12-15 | — | — | US | disclosed |
| US-9006231-B2 | Cephalotaxus esters, methods of synthesis, and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-04-14 | — | — | US | disclosed |
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-20140171416-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2014-06-19 | — | — | US | disclosed |
| WO-2009148654-A2 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-10 | — | — | WO | disclosed |
| EP-1589014-A1 | Process for the preparation of 1,3-dihydro-2H-3-benzazepin-2-one and application to the preparation of ivabradine and their pharmaceutically acceptable salts | Les Laboratoires Servier (FR) | 2005-10-26 | — | — | EP | disclosed |
| EP-0628030-B1 | 2,3,4,5-TETRAHYDRO-1H --3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF $g(a)-SUBSTITUTED-ARYLACETAMIDES | SCHERING CORP (US) | 2002-12-11 | — | — | EP | disclosed |
| EP-1011679-A1 | USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | CeNes Limited (GB) | 2000-06-28 | — | — | EP | disclosed |
| EP-0351733-B1 | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines in the treatment of neurological disorders | SCHERING CORP (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5455348-A | Anticoagulants | Thomae, Karl (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0628030-A1 | 2,3,4,5-TETRAHYDRO-1H --3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF $g(a)-SUBSTITUTED-ARYLACETAMIDES | SCHERING CORPORATION (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0351733-A1 | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines in the treatment of neurological disorders | SCHERING CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0005299-A1 | Substituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158597-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | ACHE, DDT, PTMS | PARP1 4069/4885HTR2C 3279/4885MAOB 1013/4885 |
| US-20160037771-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | ACHE, DDT, PTMS | PARP1 4069/4885HTR2C 3279/4885MAOB 1013/4885 |
| US-20140171416-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | COASY, CXCR4, CETP | PARP1 587/4885HTR2C 4799/4885MAOB 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.