Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | ACACB | O00763 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207643 | 0.80 | HRH3 (0.66) | HRH3 | |
| SCHEMBL16254562 | 0.76 | L3MBTL1 (0.53) | HRH3POLBADRB2MAPTSMN1; SMN2 | |
| SCHEMBL5210144 | 0.73 | HRH3 (0.68) | HRH3ADRB2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5209690 | 0.72 | HRH3 (0.67) | HRH3 | |
| SCHEMBL30528111 | 0.72 | SLC9A3 (0.54) | HRH3MAPTSMN1; SMN2SLC9A3MEN1 | |
| SCHEMBL22446325 | 0.71 | NAMPT (0.49) | HRH3POLBADRB2MAPTSMN1; SMN2 | |
| SCHEMBL3532274 | 0.69 | NAMPT (0.49) | ACACBMAPTNAMPTSLC9A3MEN1 | |
| SCHEMBL30441002 | 0.69 | RORC (0.52) | ACACBPOLBADRB2MAPTSMN1; SMN2 | |
| SCHEMBL943416 | 0.69 | KCNH2 (0.52) | POLBADRB2MAPTSMN1; SMN2NAMPT | |
| SCHEMBL22173978 | 0.68 | NAMPT (0.47) | HRH3POLBADRB2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311482-B1 | NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARM INC (US) | 2007-02-21 | — | — | EP | claimed |