Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204586 | 0.89 | OPRM1 (0.47) | OPRM1OPRK1OPRL1SCN1ASCN5A | |
| SCHEMBL5202784 | 0.77 | OPRM1 (0.49) | OPRM1OPRK1OPRL1SCN1ASCN5A | |
| SCHEMBL5201788 | 0.76 | OPRM1 (0.47) | OPRM1OPRK1OPRL1 | |
| SCHEMBL5204015 | 0.75 | OPRM1 (0.47) | OPRM1OPRK1OPRL1PLD1 | |
| SCHEMBL5204575 | 0.75 | OPRM1 (0.47) | OPRM1OPRK1OPRL1SCN1ASCN5A | |
| SCHEMBL5204148 | 0.74 | HTR2A (0.47) | OPRM1OPRK1OPRL1PLD1 | |
| SCHEMBL5206821 | 0.73 | KDM4E (0.37) | OPRM1OPRK1OPRL1 | |
| SCHEMBL5204779 | 0.72 | AKR1B1 (0.38) | OPRM1OPRK1OPRL1 | |
| SCHEMBL5871580 | 0.71 | SLC22A12 (0.43) | — | |
| SCHEMBL5205007 | 0.69 | ACACB (0.42) | OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |