Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121030 | 0.95 | NR1I2 (0.39) | POLBALDH1A1KDM4ESIGMAR1OPRM1 | |
| SCHEMBL5206973 | 0.93 | NR1I2 (0.41) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5207585 | 0.89 | AOC3 (0.40) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6682502 | 0.82 | POLB (0.47) | POLBALDH1A1KDM4ESIGMAR1OPRM1 | |
| SCHEMBL3046900 | 0.82 | CYP2C19 (0.43) | POLBALDH1A1KDM4ESIGMAR1OPRM1 | |
| SCHEMBL4994413 | 0.82 | POLB (0.43) | POLBALDH1A1KDM4ECNR2CTSL | |
| SCHEMBL5203967 | 0.81 | LMNA (0.43) | POLBHTR2ALMNAHRH1AOC3 | |
| SCHEMBL17183676 | 0.81 | POLB (0.39) | POLBALDH1A1KDM4ESIGMAR1OPRM1 | |
| SCHEMBL5854693 | 0.81 | POLB (0.39) | POLBALDH1A1KDM4ESIGMAR1OPRM1 | |
| SCHEMBL5854697 | 0.81 | POLB (0.39) | POLBALDH1A1KDM4ESIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980867-B1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES (JP) | 2007-08-08 | — | — | EP | disclosed |
| CN-1114602-C | Ketone derivatives and medicinal use thereof | TORAY INDUSTRIES (JP) | 2003-07-16 | — | — | CN | disclosed |
| US-6100292-A | Ketone derivatives and their medical applications | TORAY INDUSTRIES, INC. (JP) | 2000-08-08 | — | — | US | disclosed |
| EP-0980867-A1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-02-23 | — | — | EP | disclosed |
| CN-1242771-A | Ketone derivatives and medicinal use thereof | TORAY INDUSTRIES (JP) | 2000-01-26 | — | — | CN | disclosed |