SCHEMBL5202909

SCHEMBL5202909

O=C(O)Oc1cc2ccc([N+](=O)[O-])cc2s1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
CYP3A4 P08684 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
TSHR P16473 1/20 0.43
HTT P42858 1/20 0.43
POLB P06746 2/20 0.43
LMNA P02545 1/20 0.43
ALOX15 P16050 1/20 0.43
DYRK1A Q13627 1/20 0.43
PDK1 Q15118 1/20 0.42
MAPT P10636 3/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
KMT2A Q03164 3/20 0.40
PIN1 Q13526 1/20 0.40
HPGD P15428 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5235723 0.88 SMN1; SMN2 (0.56) ALDH1A1SMN1; SMN2CYP3A4TDP1TSHR
SCHEMBL5202332 0.84 SMN1; SMN2 (0.49) ALDH1A1SMN1; SMN2CYP3A4TDP1TSHR
SCHEMBL1090443 0.80 BCL2L1 (0.54) ALDH1A1SMN1; SMN2CYP3A4TDP1TSHR
SCHEMBL5202623 0.78 CA2 (0.47) ALDH1A1SMN1; SMN2CYP3A4TDP1POLB
SCHEMBL19756727 0.77 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2CYP3A4TDP1TSHR
SCHEMBL19756726 0.75 SMN1; SMN2 (0.48) ALDH1A1SMN1; SMN2CYP3A4TDP1TSHR
SCHEMBL999135 0.75 POLB (0.54) ALDH1A1SMN1; SMN2TDP1HTTPOLB
SCHEMBL5202024 0.74 RAB9A (0.39) SMN1; SMN2CYP3A4TDP1LMNADYRK1A
SCHEMBL5238184 0.74 KMT2A (0.41) ALDH1A1SMN1; SMN2TDP1TSHRHTT
SCHEMBL1884933 0.74 HDAC1 (0.60) SMN1; SMN2TDP1POLBLMNAPIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1527073-B1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS BAYER HEALTHCARE AG (DE) 2007-08-22 EP disclosed
EP-1461335-B1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-02-28 EP disclosed
EP-1527073-A1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS Bayer HealthCare AG (DE) 2005-05-04 EP disclosed
EP-1461335-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES Bayer HealthCare AG (DE) 2004-09-29 EP disclosed
WO-2004013136-A1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS BAYER HEALTHCARE AG (DE) 2004-02-12 WO disclosed
WO-2003055878-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2003-07-10 WO disclosed