Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | POLB | P06746 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NQO2 | P16083 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203706 | 0.83 | KCNK9 (0.76) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4248720 | 0.83 | RXFP1 (0.76) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL14363225 | 0.83 | POLB (0.75) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL4141962 | 0.83 | MEN1 (0.89) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL31331620 | 0.82 | ALDH1A1 (0.73) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL9638131 | 0.81 | MEN1 (0.86) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL29521706 | 0.81 | TSHR (0.70) | ALDH1A1POLBSMN1; SMN2LMNAMAPT | |
| SCHEMBL184025 | 0.81 | TSHR (0.70) | ALDH1A1POLBSMN1; SMN2LMNAMAPT | |
| SCHEMBL4098536 | 0.80 | CHEK1 (0.84) | ALDH1A1POLBMEN1KMT2ARAB9A | |
| SCHEMBL13561150 | 0.79 | MAPT (0.68) | ALDH1A1POLBMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087946-B1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| CN-1168720-C | Aryl alkanoylpyridazines | Ĭ��ר���ɷ�����˾ | 2004-09-29 | — | — | CN | disclosed |
| US-6417188-B1 | ENZYME INHIBITORS OF PHOSPHODIESTERASE | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-07-09 | — | — | US | disclosed |
| CN-1305465-A | Aryl alkanoylpyridazines | MERCK PATENT GMBH (DE) | 2001-07-25 | — | — | CN | disclosed |
| EP-1087946-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065880-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 1999-12-23 | — | — | WO | disclosed |