Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.68 |
| ▸ | INSR | P06213 | 6/20 | 0.68 |
| ▸ | JAK2 | O60674 | 10/20 | 0.68 |
| ▸ | BRD4 | O60885 | 7/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | BRD2 | P25440 | 1/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.59 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519927 | 0.91 | INSR (0.68) | ALKINSRJAK2BRD4JAK3 | |
| SCHEMBL520177 | 0.91 | JAK2 (0.72) | ALKINSRJAK2BRD4JAK3 | |
| SCHEMBL16530619 | 0.89 | ALK (0.69) | ALKINSRJAK2BRD4JAK3 | |
| SCHEMBL518914 | 0.87 | JAK2 (0.66) | ALKINSRJAK2BRD4JAK3 | |
| SCHEMBL519908 | 0.84 | JAK2 (0.80) | ALKINSRJAK2JAK3PTK2 | |
| SCHEMBL520258 | 0.84 | ALK (0.78) | ALKINSRJAK2JAK3PTK2 | |
| SCHEMBL3469388 | 0.83 | ALK (0.80) | ALKINSRJAK2JAK3PTK2 | |
| SCHEMBL520367 | 0.83 | JAK2 (0.83) | ALKINSRJAK2JAK3PTK2 | |
| SCHEMBL25223289 | 0.82 | PTK2 (0.62) | ALKINSRJAK2BRD4JAK3 | |
| SCHEMBL519632 | 0.82 | INSR (0.70) | ALKINSRJAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | claimed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | ALK 2/4885INSR 1738/4885JAK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.