Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127165 | 0.96 | HTR1A (0.50) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5203312 | 0.92 | HTR1A (0.49) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5201347 | 0.92 | ADRA2A (0.59) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5233203 | 0.92 | ADRA2A (0.51) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5202823 | 0.91 | HTR1A (0.54) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5205825 | 0.90 | HTR1A (0.53) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8140840 | 0.89 | HTR1A (0.54) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8145481 | 0.89 | ADRA2A (0.55) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8154045 | 0.89 | HTR1A (0.46) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7785392 | 0.89 | SLC6A4 (0.53) | HTR1AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |