Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31572027 | 0.90 | MMP2 (0.48) | CASP3KMT2AITGB3ITGA2BMDM4 | |
| SCHEMBL29455664 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL29528770 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL31276348 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL5967446 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL119637 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL119688 | 0.83 | MDM4 (0.59) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL23880508 | 0.81 | KMT2A (0.53) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL23880503 | 0.81 | KMT2A (0.53) | CASP3KMT2AMDM4TP53 | |
| SCHEMBL30254873 | 0.80 | KMT2A (0.58) | CASP3KMT2AMDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135374-B9 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1135374-B1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1135374-A1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6204282-B1 | TREATING CANCER, RETINOPATHY, ATHEROSCLEROSIS, VASCULAR RESTENOSIS, OR OSTEOPOROSIS. | SCHERING CORPORATION | 2001-03-20 | — | — | US | disclosed |
| WO-2000032578-A1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2000-06-08 | — | — | WO | disclosed |