Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780297 | 0.94 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787387 | 0.93 | SLC6A4 (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5203742 | 0.91 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8124382 | 0.90 | HTR1A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7788881 | 0.90 | HTR1A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5203699 | 0.89 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5201819 | 0.89 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5200629 | 0.88 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7784866 | 0.87 | SLC6A4 (0.48) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5200540 | 0.87 | HTR1A (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |