Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656553 | 0.87 | DNM1 (0.40) | GAAEPHX1CA1CA2DNM1 | |
| SCHEMBL7673548 | 0.83 | CA1 (0.43) | EPHX1CA1CA2DNM1LMNA | |
| SCHEMBL8639866 | 0.81 | DNM1 (0.50) | EPHX1CA1CA2DNM1LMNA | |
| SCHEMBL13207719 | 0.81 | CYP4F2 (0.37) | GAAALDH1A1 | |
| SCHEMBL28389824 | 0.79 | DNM1 (0.53) | EPHX1DNM1LMNAALDH1A1 | |
| SCHEMBL4141679 | 0.79 | DNM1 (0.53) | EPHX1DNM1LMNAALDH1A1 | |
| SCHEMBL28945728 | 0.79 | DNM1 (0.53) | EPHX1DNM1LMNAALDH1A1 | |
| SCHEMBL25429944 | 0.78 | — | — | |
| SCHEMBL14966446 | 0.78 | — | — | |
| SCHEMBL6001516 | 0.78 | DNM1 (0.34) | EPHX1CA1CA2DNM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556372-B1 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1556372-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041806-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2004-05-21 | — | — | WO | disclosed |