Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206840 | 1.00 | BAZ2A (0.39) | BAZ2APOLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21162019 | 0.84 | POLB (0.47) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL5201481 | 0.79 | NPSR1 (0.40) | ALDH1A1CYP2C19SMN1; SMN2GAAMAPK1 | |
| SCHEMBL5168128 | 0.78 | POLB (0.43) | BAZ2APOLBALDH1A1KDM4EHPGD | |
| SCHEMBL2231946 | 0.76 | POLB (0.57) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL6500497 | 0.76 | DRD2 (0.50) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL2479293 | 0.75 | POLB (0.56) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5171724 | 0.75 | ALDH1A1 (0.54) | POLBSLC6A4ALDH1A1CYP2C19SMN1; SMN2 | |
| Formic Acid SCHEMBL3897717 | 0.74 | POLB (0.39) | BAZ2APOLBALDH1A1KDM4EHPGD | |
| Formic Acid SCHEMBL27679268 | 0.72 | POLB (0.39) | BAZ2APOLBALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |