Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.36 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205013 | 0.82 | KCNH2 (0.40) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL7708449 | 0.82 | NPC1 (0.45) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| Hydrochloric Acid SCHEMBL7714006 | 0.81 | KDM4E (0.44) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL5207711 | 0.81 | SCN9A (0.43) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL1376217 | 0.81 | NUDT1 (0.43) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL5205246 | 0.80 | SCN9A (0.45) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL5202871 | 0.80 | STK17A (0.42) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL1375417 | 0.79 | SCN9A (0.40) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL5203245 | 0.79 | SCN9A (0.40) | SCN9AKCNH2SCN5ACCNCCDK8 | |
| SCHEMBL5204559 | 0.79 | STK17A (0.41) | SCN9AKCNH2SCN5ACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |