Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207711 | 0.83 | SCN9A (0.43) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL5205013 | 0.82 | KCNH2 (0.40) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL5203245 | 0.81 | SCN9A (0.40) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL1375417 | 0.81 | SCN9A (0.40) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL5204622 | 0.81 | SCN9A (0.51) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| Hydrochloric Acid SCHEMBL5203439 | 0.80 | SCN9A (0.50) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL1376217 | 0.80 | NUDT1 (0.43) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL5204086 | 0.80 | SCN9A (0.39) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL5203452 | 0.80 | P2RX3 (0.49) | SCN9AKCNH2SCN5ACDK8CCNC | |
| SCHEMBL1379499 | 0.79 | MEN1 (0.39) | SCN9AKCNH2SCN5ACDK8CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |