Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | NPM1 | P06748 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.48 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | QDPR | P09417 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519815 | 0.87 | ALK (0.51) | INSRNPM1ALKCCNT1CDK9 | |
| SCHEMBL28209999 | 0.84 | QDPR (0.49) | CCR5PDE4BQDPRDRD2 | |
| SCHEMBL520850 | 0.84 | MEN1 (0.50) | CCNT1CDK9TLR9TLR8TLR7 | |
| SCHEMBL28368871 | 0.83 | PDE4B (0.47) | INSRNPM1ALKCCR5PDE4B | |
| SCHEMBL520643 | 0.82 | PDE4B (0.46) | INSRNPM1ALKCCR5PDE4B | |
| SCHEMBL520283 | 0.81 | PDE4B (0.51) | INSRNPM1ALKPDE4BQDPR | |
| SCHEMBL16530506 | 0.81 | QDPR (0.46) | TLR9TLR8TLR7CCR5PDE4B | |
| SCHEMBL3345349 | 0.81 | QDPR (0.45) | CCR5PDE4BQDPRDRD2 | |
| SCHEMBL20725583 | 0.80 | QDPR (0.49) | QDPRDRD2 | |
| SCHEMBL519694 | 0.79 | QDPR (0.52) | QDPRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | INSR 1738/4885NPM1 1309/4885ALK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.