Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345716 | 0.86 | PDE4B (0.45) | PDE4BDRD2 | |
| SCHEMBL20725583 | 0.84 | QDPR (0.49) | QDPRHTR4ALDH1A1KCNH2CHRM4 | |
| SCHEMBL15652646 | 0.83 | QDPR (0.44) | QDPRPDE4BHTR4ALDH1A1CCR5 | |
| SCHEMBL28869444 | 0.83 | QDPR (0.48) | QDPRPDE4BHTR4ALDH1A1CCR5 | |
| SCHEMBL3348766 | 0.82 | PDE4B (0.39) | QDPRPDE4BHTR4ALDH1A1 | |
| SCHEMBL310593 | 0.82 | DRD2 (0.62) | QDPRHTR4KCNH2CHRM4CHRM5 | |
| SCHEMBL2913286 | 0.81 | HDAC1 (0.36) | DRD2CARM1 | |
| SCHEMBL519815 | 0.81 | ALK (0.51) | QDPRPDE4BHTR4CCR5CHRM4 | |
| SCHEMBL520437 | 0.81 | INSR (0.52) | QDPRPDE4BCCR5DRD2 | |
| SCHEMBL310493 | 0.81 | QDPR (0.46) | QDPRHTR4KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |