Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 15/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202065 | 1.00 | RORC (0.49) | RORCSTSKMT2AMEN1SIRT2 | |
| SCHEMBL5202070 | 1.00 | RORC (0.49) | RORCSTSKMT2AMEN1SIRT2 | |
| SCHEMBL6793605 | 0.92 | RORC (0.48) | RORCSTSSIRT2SIRT1CCR5 | |
| SCHEMBL6793598 | 0.92 | RORC (0.48) | RORCSTSSIRT2SIRT1CCR5 | |
| SCHEMBL5203325 | 0.90 | STS (0.39) | RORCSTSKMT2AL3MBTL1CCR5 | |
| SCHEMBL5203332 | 0.90 | STS (0.39) | RORCSTSKMT2AL3MBTL1CCR5 | |
| SCHEMBL6296895 | 0.78 | MEN1 (0.49) | RORCKMT2AMEN1 | |
| SCHEMBL6296896 | 0.78 | MEN1 (0.49) | RORCKMT2AMEN1 | |
| SCHEMBL5201579 | 0.78 | MEN1 (0.49) | RORCKMT2AMEN1 | |
| SCHEMBL5323846 | 0.78 | MEN1 (0.49) | RORCKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389200-A4 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2007-03-28 | — | — | EP | disclosed |
| EP-1389200-A1 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | Merck & Co., Inc. (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002074761-A1 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2002-09-26 | — | — | WO | disclosed |