Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 12/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5168875 | 0.90 | PSEN1 (0.47) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL5170546 | 0.88 | PSEN1 (0.41) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL5167536 | 0.88 | PSEN1 (0.57) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL5170727 | 0.86 | MMP2 (0.41) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL5168403 | 0.85 | PSEN1 (0.41) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL5168620 | 0.83 | PSEN1 (0.48) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL9294341 | 0.74 | KCNQ2 (0.53) | AKR1C3AKR1C2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6475463 | 0.74 | PSEN1 (0.59) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL4597558 | 0.74 | AKR1C3 (0.65) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL1903665 | 0.73 | AKR1C3 (0.59) | AKR1C3AKR1C2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773315-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006008558-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-26 | — | — | WO | disclosed |