Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205873 | 0.84 | HRH2 (0.51) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5205803 | 0.83 | HRH2 (0.50) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5203151 | 0.83 | ALDH1A1 (0.50) | HRH2ALDH1A1 | |
| SCHEMBL27559062 | 0.82 | HRH2 (0.59) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL4852063 | 0.81 | HRH2 (0.53) | HRH2HTR2AHTR2CHTR2BTPSAB1 | |
| SCHEMBL4852959 | 0.81 | SMN1; SMN2 (0.53) | HRH2HTR2AHTR2CHTR2BTPSAB1 | |
| SCHEMBL4849757 | 0.80 | HRH2 (0.47) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5201671 | 0.78 | ALDH1A1 (0.51) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL27478068 | 0.78 | HRH2 (0.55) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL6781803 | 0.77 | HRH2 (0.65) | HRH2HTR2AHTR2CHTR2BCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |