Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5818040 | 0.87 | SLC2A1 (0.47) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4859500 | 0.86 | KMT2A (0.52) | HRH2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5205671 | 0.85 | MAPT (0.47) | HRH2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5204952 | 0.84 | HRH2 (0.55) | HRH2HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL5203803 | 0.81 | MAPT (0.52) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4852063 | 0.77 | HRH2 (0.53) | HRH2HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL4849757 | 0.75 | HRH2 (0.47) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5205803 | 0.75 | HRH2 (0.50) | HRH2HTR2AHTR2CHTR2BCNR2 | |
| SCHEMBL5202640 | 0.74 | HRH2 (0.43) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL27559062 | 0.74 | HRH2 (0.59) | HRH2HTR2AHTR2CHTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |