Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200288 | 0.91 | ADORA1 (0.56) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL4115414 | 0.77 | MAPT (0.51) | ADORA1ADORA2AADORA3MAPK14MAPT | |
| SCHEMBL5203671 | 0.72 | MAPK14 (0.48) | MAPK14MAPK1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL5202308 | 0.72 | MAPK14 (0.53) | ADORA1ADORA2AADORA3MAPK14ADORA2B | |
| SCHEMBL3891736 | 0.71 | MAPK14 (0.51) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL3888866 | 0.71 | ADORA3 (0.57) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL3071322 | 0.71 | ADORA3 (0.62) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL3892411 | 0.70 | ADORA3 (0.69) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL6282526 | 0.70 | MAPK14 (0.61) | ADORA1ADORA2AADORA3MAPK14CHRM5 | |
| SCHEMBL6500341 | 0.70 | ADORA3 (0.68) | ADORA1ADORA2AADORA3MAPK14CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199124-B2 | JNK inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040063946-A1 | Jnk inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1402900-A1 | MEDICINAL COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1364949-A1 | JNK INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 2003-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063946-A1 | Jnk inhibitor | MAPK1, MAPK7, MAP3K7 | ADORA1 4358/4885ADORA2A 4636/4885ADORA3 4587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.