Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | TSPO | P30536 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892411 | 0.92 | ADORA3 (0.69) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL5792342 | 0.88 | MAPK14 (0.74) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL5205132 | 0.84 | MAPK14 (0.62) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL3890123 | 0.84 | MAPK14 (0.61) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL3887439 | 0.84 | ADORA3 (0.81) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL5804809 | 0.83 | MAPK14 (0.59) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL5805510 | 0.83 | MAPK14 (0.59) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL5804807 | 0.83 | MAPK14 (0.59) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL3900986 | 0.83 | MAPK14 (0.60) | ADORA3ADORA1ADORA2ACHRM5HTR2A | |
| SCHEMBL3888866 | 0.83 | ADORA3 (0.57) | ADORA3ADORA1ADORA2ACHRM5HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
| EP-1402900-A1 | MEDICINAL COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-20040053973-A1 | Substituted 1,3-thiazole compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | ADORA3 1613/4885ADORA1 1594/4885ADORA2A 1487/4885 |
| US-20040053973-A1 | Substituted 1,3-thiazole compounds, their production and use | MAPK1, MAP4K2, MAPK4 | ADORA3 3759/4885ADORA1 3999/4885ADORA2A 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.