Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202645 | 0.85 | PTGS2 (0.53) | SMN1; SMN2ALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL5201918 | 0.85 | MAPK13 (0.46) | SMN1; SMN2MEN1KMT2AMAPK10LMNA | |
| SCHEMBL5203715 | 0.85 | LMNA (0.43) | ALDH1A1KDM4EMEN1USP2POLB | |
| SCHEMBL10585221 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1ALDH1A1MAPTNPSR1 | |
| SCHEMBL6165726 | 0.84 | KDM4E (0.44) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EPOLB | |
| SCHEMBL5865561 | 0.82 | PTGS1 (0.42) | SMN1; SMN2L3MBTL1ALDH1A1ALDH1A3KDM4E | |
| SCHEMBL6885923 | 0.79 | NR1H3 (0.57) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL6883364 | 0.77 | POLB (0.48) | SMN1; SMN2ALDH1A1MEN1POLBMAPT | |
| SCHEMBL5207846 | 0.76 | PTGS2 (0.62) | SMN1; SMN2PTGS2 | |
| SCHEMBL11020712 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458706-B1 | DIARYL 1,2,4-TRIAZOLE DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CJ CORP (KR) | 2007-07-11 | — | — | EP | disclosed |
| US-7169929-B2 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2007-01-30 | — | — | US | disclosed |
| US-7135572-B2 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP (KR) | 2006-11-14 | — | — | US | disclosed |
| US-20060009495-A1 | Diary 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2006-01-12 | — | — | US | disclosed |
| US-20050075373-A1 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | CJ CORP. (KR) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009495-A1 | Diary 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | PTGS1, PTGS2, PTGES2 | SMN1; SMN2 4607/4885L3MBTL1 3088/4885ALDH1A1 110/4885 |
| US-20050075373-A1 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor | PTGS1, PTGS2, PTGES2 | SMN1; SMN2 4701/4885L3MBTL1 3168/4885ALDH1A1 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.