Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25430300 | 0.84 | KDM4E (0.51) | KDM4EALOX15L3MBTL1TGFBR1ADORA2A | |
| SCHEMBL367849 | 0.78 | ADORA2A (0.61) | KDM4EALOX15L3MBTL1TGFBR1ADORA2A | |
| SCHEMBL30455036 | 0.75 | KCNH2 (0.43) | KDM4EALOX15L3MBTL1TGFBR1LMNA | |
| SCHEMBL26260016 | 0.73 | KDM4E (0.58) | KDM4EALOX15L3MBTL1TGFBR1LMNA | |
| SCHEMBL6824538 | 0.72 | KDM4E (0.50) | KDM4EALOX15L3MBTL1TGFBR1ADORA2A | |
| Dipyridyl SCHEMBL29167113 | 0.70 | KDM4E (0.79) | KDM4EALOX15L3MBTL1LMNACCR1 | |
| SCHEMBL13728155 | 0.70 | NPC1 (0.52) | KDM4EALOX15L3MBTL1TGFBR1LMNA | |
| SCHEMBL13726458 | 0.69 | TGFBR1 (0.49) | KDM4EALOX15L3MBTL1TGFBR1LMNA | |
| SCHEMBL4106450 | 0.69 | ADORA2A (0.47) | KDM4EALOX15L3MBTL1TGFBR1ADORA2A | |
| SCHEMBL2061612 | 0.68 | KDM4E (0.70) | KDM4EALOX15L3MBTL1TGFBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742634-A1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAgen, Incorporated (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005099711-A1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |