Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203602 | 0.94 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5205465 | 0.91 | MAPK14 (0.50) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5205260 | 0.90 | MAPK14 (0.49) | MAPK14CYP2C9CYP2C19DNMT3ACCR3 | |
| SCHEMBL5202103 | 0.89 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5201216 | 0.89 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5207420 | 0.88 | MAPK14 (0.52) | MAPK14CYP2C9CYP2C19DNMT3ACCR3 | |
| SCHEMBL5205224 | 0.84 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5201330 | 0.84 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19TP53 | |
| SCHEMBL5204360 | 0.84 | MAPK14 (0.50) | MAPK14CYP2C9CYP2C19TP53L3MBTL1 | |
| SCHEMBL5202149 | 0.82 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19CCR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |