Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 14/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920897 | 0.95 | ALDH1A1 (0.52) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL3921282 | 0.89 | ALDH1A1 (0.52) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL6584572 | 0.88 | NPC1 (0.45) | PGRALDH1A1GAAPOLBMAPT | |
| SCHEMBL3927077 | 0.87 | ALDH1A1 (0.50) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL6604789 | 0.86 | MAOB (0.59) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL13210796 | 0.86 | ALDH1A1 (0.53) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL5202716 | 0.84 | ALDH1A1 (0.49) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL143747 | 0.84 | ALDH1A1 (0.48) | PGRALDH1A1GAAPOLBLMNA | |
| SCHEMBL6581799 | 0.83 | NPC1 (0.45) | PGRALDH1A1POLBLMNAMAPT | |
| SCHEMBL13210770 | 0.83 | ALDH1A1 (0.52) | PGRALDH1A1GAAPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087946-B1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| CN-1168720-C | Aryl alkanoylpyridazines | Ĭ��ר���ɷ�����˾ | 2004-09-29 | — | — | CN | disclosed |
| US-6417188-B1 | ENZYME INHIBITORS OF PHOSPHODIESTERASE | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-07-09 | — | — | US | disclosed |
| CN-1305465-A | Aryl alkanoylpyridazines | MERCK PATENT GMBH (DE) | 2001-07-25 | — | — | CN | disclosed |
| EP-1087946-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065880-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 1999-12-23 | — | — | WO | disclosed |