Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207644 | 0.88 | MAPT (0.35) | MAPTNPC1RAB9AICAM1SELE | |
| SCHEMBL5206305 | 0.85 | MAPT (0.33) | MAPTNPC1RAB9AICAM1SELE | |
| SCHEMBL5207523 | 0.85 | CCNC (0.39) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1375252 | 0.76 | MAPT (0.41) | MAPTSMN1; SMN2NPC1RAB9AICAM1 | |
| SCHEMBL5206507 | 0.74 | SLC6A2 (0.39) | MAPTSMN1; SMN2NPC1RAB9AICAM1 | |
| SCHEMBL6480339 | 0.74 | MAPT (0.44) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7157258 | 0.74 | MERTK (0.42) | MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5207653 | 0.74 | POLB (0.38) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7157262 | 0.74 | MERTK (0.42) | MAPTSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5203349 | 0.73 | MERTK (0.41) | MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |