Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TTR | P02766 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | CBR1 | P16152 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202529 | 0.89 | MET (0.41) | SLC6A2SLC6A3SLC6A4KDRP2RX3 | |
| SCHEMBL5206507 | 0.89 | SLC6A2 (0.39) | POLBHPGDMAPTLMNASLC6A2 | |
| SCHEMBL5203877 | 0.89 | NPC1 (0.36) | SLC6A2SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL5207523 | 0.85 | CCNC (0.39) | HPGDMAPTALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL5206305 | 0.76 | MAPT (0.33) | MAPTLMNAALDH1A1PTGS1PTGS2 | |
| SCHEMBL5207644 | 0.76 | MAPT (0.35) | POLBHPGDMAPTLMNAALDH1A1 | |
| SCHEMBL5203455 | 0.75 | TTR (0.40) | POLBHPGDMAPTLMNATTR | |
| SCHEMBL6482628 | 0.74 | BCL6 (0.44) | POLBHPGDMAPTLMNATTR | |
| SCHEMBL5203220 | 0.74 | MERTK (0.39) | POLBHPGDMAPTLMNATTR | |
| SCHEMBL5203216 | 0.74 | MERTK (0.39) | POLBHPGDMAPTLMNATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |