Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520305 | 0.86 | SIRT6 (0.42) | SIRT6ADRB1LMNAALDH1A1HPGD | |
| SCHEMBL493568 | 0.80 | CACNA2D1 (0.52) | CACNA2D1CACNA1BCACNB1OPRM1OPRD1 | |
| SCHEMBL519356 | 0.80 | SIRT6 (0.51) | SIRT6CACNA2D1CACNA1BCACNB1LMNA | |
| SCHEMBL493178 | 0.80 | CACNA2D1 (0.61) | CACNA2D1CACNA1BCACNB1KCNH2OPRM1 | |
| SCHEMBL4941263 | 0.74 | CXCR4 (0.46) | CACNA2D1CACNA1BCACNB1OPRM1OPRD1 | |
| SCHEMBL493622 | 0.71 | CACNA2D1 (0.46) | CACNA2D1CACNA1BCACNB1KCNH2CACNA1C | |
| SCHEMBL3935054 | 0.70 | SIRT6 (0.53) | SIRT6LMNAALDH1A1HPGDKCNJ1 | |
| SCHEMBL4045417 | 0.70 | SLC6A3 (0.49) | SIRT6ADRB1ALDH1A1GAASLC6A3 | |
| SCHEMBL4819678 | 0.70 | CHRM2 (0.57) | SIRT6ADRB1ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL24993177 | 0.69 | MAPT (0.53) | SIRT6LMNAALDH1A1HPGDKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | SIRT6 3364/4885CACNA2D1 852/4885CACNA1B 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.