Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 3/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207133 | 0.88 | MAPK14 (0.46) | MAPK14P2RX3APLNR | |
| SCHEMBL5204954 | 0.87 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL5206635 | 0.85 | MAPK14 (0.38) | MAPK14 | |
| SCHEMBL5240579 | 0.84 | MAPK14 (0.39) | MAPK14P2RX3APLNR | |
| SCHEMBL5241553 | 0.79 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL4512780 | 0.76 | MAPK14 (0.50) | MAPK14 | |
| SCHEMBL3523763 | 0.76 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL5202334 | 0.75 | MAPK14 (0.44) | MAPK14CNR1 | |
| SCHEMBL5209531 | 0.74 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL5202360 | 0.73 | MAPK14 (0.37) | MAPK14P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |