Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581721 | 0.91 | EGFR (0.42) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL29364990 | 0.89 | EGFR (0.50) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL12414 | 0.89 | EGFR (0.50) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL30502330 | 0.89 | EGFR (0.50) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL7000618 | 0.87 | EGFR (0.42) | EGFRALDH1A1METAP2METAP1NPC1 | |
| SCHEMBL30876200 | 0.87 | EGFR (0.48) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| Quinoline SCHEMBL27968729 | 0.84 | ALDH1A1 (0.59) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL29048833 | 0.83 | EGFR (0.41) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| Quinazoline SCHEMBL6130196 | 0.81 | EGFR (0.69) | EGFRALDH1A1PIK3CDPIK3CAMETAP2 | |
| SCHEMBL88611 | 0.78 | ALDH1A1 (0.55) | ALDH1A1NPC1POLBRAB9ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809621-A1 | METHODS OF PREPARING INDAZOLE COMPOUNDS | Pfizer, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048744-A1 | METHODS OF PREPARING INDAZOLE COMPOUNDS | PFIZER INC. (US) | 2006-05-11 | — | — | WO | disclosed |