Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27968729 | 0.90 | ALDH1A1 (0.59) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Quinoxaline SCHEMBL150387 | 0.87 | EGFR (0.83) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Acridine SCHEMBL27559723 | 0.85 | ALDH1A1 (0.50) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Quinazoline SCHEMBL29490398 | 0.83 | EGFR (1.00) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Quinazoline SCHEMBL29356169 | 0.83 | EGFR (1.00) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Quinazoline SCHEMBL22833783 | 0.83 | EGFR (1.00) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| Quinazoline SCHEMBL5920 | 0.83 | EGFR (1.00) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB | |
| SCHEMBL7000618 | 0.82 | EGFR (0.42) | EGFRALDH1A1METAP2METAP1CYP1A2 | |
| SCHEMBL29048833 | 0.82 | EGFR (0.41) | EGFRPIK3CDPIK3CAALDH1A1CYP2A6 | |
| Quinoline SCHEMBL156755 | 0.82 | EGFR (0.80) | EGFRPIK3CDPIK3CAALDH1A1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389909-A4 | ANTIMICROBIAL COMPOUNDS AND METHODS FOR THEIR USE | OLIGOS ETC INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1389909-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS FOR THEIR USE | Oligos Etc. Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002089581-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS FOR THEIR USE | OLIGOS ETC. INC. (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-1999011622-A1 | AMINO-SUBSTITUTED COMPOUNDS, METHODS, AND COMPOSITIONS FOR INHIBITING PARP ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1999-03-11 | — | — | WO | disclosed |