Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 14/20 | 0.53 |
| ▸ | CCR2 | P41597 | 3/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.47 |
| ▸ | CCR7 | P32248 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204042 | 0.84 | GFER (0.42) | CCR5GFEROPRM1OPRD1NPC1 | |
| SCHEMBL5210006 | 0.76 | CCR5 (0.52) | CCR5CCR2CXCR3CCR7NPC1 | |
| SCHEMBL5208454 | 0.76 | CCR5 (0.70) | CCR5CCR2CXCR3CCR7 | |
| SCHEMBL5204923 | 0.75 | CCR5 (0.52) | CCR5CCR2CXCR3CCR7NPC1 | |
| SCHEMBL5209313 | 0.72 | CCR5 (0.74) | CCR5CCR2CXCR3CCR7CXCR5 | |
| SCHEMBL15095777 | 0.72 | CCR5 (0.74) | CCR5CCR2CXCR3CCR7CXCR5 | |
| SCHEMBL3499816 | 0.72 | CCR5 (0.53) | CCR5CCR2CXCR3CCR7NPC1 | |
| SCHEMBL5210198 | 0.71 | CCR5 (0.73) | CCR5CCR2CXCR3CCR7CXCR5 | |
| SCHEMBL5209488 | 0.70 | CCR5 (0.69) | CCR5CCR2CXCR3CCR7 | |
| SCHEMBL7676932 | 0.70 | CCR5 (0.47) | CCR5CCR2CXCR3CCR7CXCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040103-B1 | ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2007-03-14 | — | — | EP | disclosed |
| US-6413947-B1 | Anilide derivative, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-02 | — | — | US | disclosed |
| US-6172061-B1 | AIDS THERAPY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| US-6166006-A | Anilide derivative, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-1039899-A2 | PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE | Takeda Chemical Industries, Ltd. (JP) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032100-A2 | PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-01 | — | — | WO | disclosed |