Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203048 | 0.87 | MEN1 (0.54) | LMNAMEN1KMT2AHPGDGFER | |
| SCHEMBL4490500 | 0.86 | CTNNB1 (0.51) | LMNAMEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL5207437 | 0.86 | MEN1 (0.64) | LMNAMEN1KMT2AHPGDGFER | |
| SCHEMBL4501469 | 0.83 | APEX1 (0.49) | LMNAMEN1KMT2AHPGDGFER | |
| Methanesulfonamide SCHEMBL4500516 | 0.82 | MEN1 (0.49) | LMNAMEN1KMT2AHPGDGFER | |
| Benzenesulfonamide SCHEMBL4496281 | 0.80 | MEN1 (0.48) | LMNAMEN1KMT2AHPGDGFER | |
| SCHEMBL4482149 | 0.80 | KDM4E (0.47) | MEN1KMT2AEGFRAKR1C3AKR1C2 | |
| SCHEMBL4487073 | 0.80 | KDM4E (0.53) | MEN1KMT2AHPGDEGFRAKR1C3 | |
| SCHEMBL4489260 | 0.79 | HPGDS (0.55) | LMNAHPGDSMN1; SMN2EGFRNPC1 | |
| SCHEMBL5202789 | 0.79 | AKR1C3 (0.60) | LMNAMEN1KMT2AHPGDGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372654-A4 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SMITHKLINE BEECHAM CORP (US) | 2007-10-03 | — | — | EP | claimed |
| EP-1372654-A2 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SmithKline Beecham Corporation (US) | 2004-01-02 | — | — | EP | claimed |
| WO-2002081728-A2 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-17 | — | — | WO | claimed |