Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 13/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 7/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.49 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.49 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5208565 | 1.00 | HDAC1 (0.61) | HDAC1PTGS2AKR1C3AKR1C4AKR1C2 | |
| SCHEMBL3173354 | 0.85 | PIK3C3 (0.49) | HDAC1PTGS2AKR1C3AKR1C4AKR1C2 | |
| SCHEMBL3173358 | 0.85 | PIK3C3 (0.49) | HDAC1PTGS2AKR1C3AKR1C4AKR1C2 | |
| SCHEMBL29087763 | 0.81 | AKR1C3 (0.48) | HDAC1PTGS2AKR1C3PIM2KDM1A | |
| SCHEMBL27522662 | 0.81 | PIM2 (0.46) | HDAC1PTGS2AKR1C3AKR1C4AKR1C2 | |
| SCHEMBL9757067 | 0.80 | HCAR2 (0.48) | HDAC1PTGS2PIM2HDAC6RAB9A | |
| SCHEMBL9757071 | 0.80 | HCAR2 (0.48) | HDAC1PTGS2PIM2HDAC6RAB9A | |
| SCHEMBL1510040 | 0.80 | FOS (0.59) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL11826245 | 0.80 | FOS (0.59) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL5206315 | 0.78 | AKR1C3 (0.55) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040103-B1 | ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2007-03-14 | — | — | EP | disclosed |
| US-6627651-B1 | Exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group and inhibitors of HIV (human | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| US-6413947-B1 | Anilide derivative, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1182195-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-6268354-B1 | Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-07-31 | — | — | US | disclosed |
| US-6172061-B1 | AIDS THERAPY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| US-6166006-A | Anilide derivative, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-1039899-A2 | PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE | Takeda Chemical Industries, Ltd. (JP) | 2000-10-04 | — | — | EP | disclosed |
| EP-1040103-A1 | ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032100-A2 | PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-01 | — | — | WO | disclosed |
| WO-1999032468-A1 | ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-01 | — | — | WO | disclosed |