Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547123 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNACYP2C9CYP1A2 | |
| SCHEMBL5623700 | 0.77 | KDM4E (0.39) | ALDH1A1MAPTLMNACYP2C9CYP1A2 | |
| SCHEMBL5207796 | 0.76 | CYP3A4 (0.52) | MAPTCYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL6628469 | 0.76 | RXFP1 (0.39) | ALDH1A1MAPTCYP1A2CYP3A4KMT2A | |
| SCHEMBL5206460 | 0.75 | CA12 (0.35) | ALDH1A1MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL5206042 | 0.75 | CA12 (0.35) | ALDH1A1MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL25077426 | 0.74 | MAPT (0.54) | ALDH1A1MAPTLMNACYP2C9CYP1A2 | |
| SCHEMBL24340392 | 0.74 | KDM4E (0.42) | ALDH1A1MAPTLMNACYP2C9CYP1A2 | |
| SCHEMBL5208181 | 0.73 | CNKSR1 (0.35) | ALDH1A1MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL28661191 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNACYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403250-B1 | BIS(5-ARYL-2-PYRIDYL) DERIVATIVE | KOWA CO (JP) | 2007-07-18 | — | — | EP | disclosed |
| EP-1403251-B1 | BIS(2-ARYL-5-PYRIDYL) DERIVATIVE | KOWA CO (JP) | 2007-07-18 | — | — | EP | disclosed |
| EP-1403250-A1 | BIS(5-ARYL-2-PYRIDYL) DERIVATIVE | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1403251-A1 | BIS(2-ARYL-5-PYRIDYL) DERIVATIVE | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |