SCHEMBL5208884

SCHEMBL5208884

CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2NCCC(=O)NCCc2ccccc2F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
P2RX4 Q99571 1/20 0.38
CNR1 P21554 1/20 0.38
PPARG P37231 4/20 0.38
PPARD Q03181 4/20 0.38
PPARA Q07869 4/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
ATM Q13315 1/20 0.37
AHCY P23526 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
LTA4H P09960 1/20 0.36
EPHX2 P34913 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5203560 0.89 ALDH1A1 (0.45) KDM4EALDH1A1P2RX4AHCYMAPT
SCHEMBL5205300 0.81 PPARG (0.41) KDM4EALDH1A1PPARGPPARDPPARA
SCHEMBL5202191 0.81 PPARG (0.42) ALDH1A1PPARGPPARDPPARAHTT
SCHEMBL5201851 0.79 ALDH1A1 (0.39) KDM4EALDH1A1P2RX4PPARGPPARD
SCHEMBL5205312 0.78 PPARG (0.40) KDM4EALDH1A1PPARGPPARDPPARA
SCHEMBL5202903 0.77 PPARG (0.40) ALDH1A1PPARGPPARDPPARAEPHX2
SCHEMBL5205234 0.77 TSHR (0.46) PPARGPPARDPPARA
SCHEMBL7833900 0.77 ALDH1A1 (0.43) KDM4EALDH1A1P2RX4PPARGPPARD
SCHEMBL5208682 0.77 PPARG (0.39) PPARGPPARDPPARAEPHX2
SCHEMBL5205112 0.77 MEN1 (0.37) KDM4EALDH1A1P2RX4CNR1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed