Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR1 | P47211 | 8/20 | 0.47 |
| ▸ | GALR2 | O43603 | 6/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451772 | 0.78 | GALR1 (0.56) | GALR1GALR2ABCG2ABCB1ABCC1 | |
| SCHEMBL3453011 | 0.78 | GALR1 (0.60) | GALR1GALR2ABCG2ABCB1ABCC1 | |
| SCHEMBL3450563 | 0.78 | GALR1 (0.58) | GALR1GALR2ABCG2ABCB1ABCC1 | |
| SCHEMBL3450914 | 0.76 | GALR1 (0.56) | GALR1GALR2ABCG2ABCB1ABCC1 | |
| SCHEMBL3451556 | 0.67 | HRH4 (0.56) | GALR1GALR2IMPDH2AURKA | |
| SCHEMBL3450918 | 0.67 | TUBB4A (0.48) | GALR1GALR2IMPDH2 | |
| SCHEMBL3450716 | 0.67 | BCL6 (0.52) | GALR1GALR2IMPDH2JAK2AURKA | |
| SCHEMBL3449850 | 0.67 | BCL6 (0.52) | GALR1GALR2IMPDH2 | |
| SCHEMBL13127185 | 0.66 | AGTR1 (0.54) | ABCG2ABCB1ABCC1AGTR1IMPDH2 | |
| SCHEMBL3452098 | 0.66 | MALT1 (0.47) | GALR1GALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796673-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034473-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-03-30 | — | — | WO | claimed |