Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209238 | 0.92 | AKR1C2 (0.59) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5274070 | 0.90 | AKR1C2 (0.58) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5214528 | 0.82 | AKR1C2 (0.61) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5211125 | 0.82 | AKR1C2 (0.58) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5208935 | 0.80 | MEN1 (0.62) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5208570 | 0.80 | AKR1C2 (0.59) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| Deboxamet SCHEMBL186946 | 0.80 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| Deboxamet SCHEMBL29387753 | 0.80 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5210270 | 0.79 | AKR1C2 (0.60) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5206552 | 0.79 | AKR1C2 (0.63) | AKR1C2MTNR1AMTNR1BHDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | disclosed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| EP-1343757-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050031-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |